[HTML][HTML] Design and synthesis of new 4-(3, 4, 5-trimethoxyphenyl) thiazole–pyrimidine derivatives as potential antiproliferative agents

AK El-Damasy, H Jin, MA Sabry, HJ Kim, MM Alanazi… - Medicina, 2023 - mdpi.com
3,4,5-trimethoxyphenyl thiazole pyrimidines has been synthesized and biologically evaluated
… of anticancer agents and generate new TMP thiazole derivatives with good anticipated …

Synthesis and biological evaluation of 4-amino-5-cinnamoylthiazoles as chalcone-like anticancer agents

A Ayati, R Esmaeili, S Moghimi, TO Bakhshaiesh… - European journal of …, 2018 - Elsevier
… Our results indicate that thiazole-based chalcones could be … are needed to obtain highly
potent anticancer agents. … ,5′-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents

Design, computational studies, synthesis and biological evaluation of thiazole-based molecules as anticancer agents

S Patel, R Patle, P Parameswaran, A Jain… - European Journal of …, 2019 - Elsevier
… Herein, we describe our efforts for the synthesis of thiazole-based novel molecules through
a multistep synthetic approach and discovery of promising anticancer hits. Firstly, the thiazole

Synthesis and biological evaluation of new coumarins bearing 2, 4-diaminothiazole-5-carbonyl moiety

A Ayati, TO Bakhshaiesh, S Moghimi, R Esmaeili… - European journal of …, 2018 - Elsevier
… -2-ones 3 and 3-(4-amino-2-(arylamino) thiazole-5-carbonyl)-2H-chromen-2-ones 4 as new
anticancer agents. The target … ′,5′-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents

2, 4, 5-trisubstituted thiazole: A privileged scaffold in drug design and activity improvement

Z Zhang, B Shu, Y Zhang, GS Deora… - Current Topics in …, 2020 - ingentaconnect.com
… Among them, tubulin has now become an attractive target for anti-tumor drugs [59]. In …
of the thiazole ring and gained the 2-substituted-4(3’,4’,5’-trimethoxy-phenyl)-5-aryl thiazole

[HTML][HTML] Synthesis and biological evaluation of 2-methyl-4, 5-disubstituted oxazoles as a novel class of highly potent antitubulin agents

R Romagnoli, PG Baraldi, F Prencipe, P Oliva… - Scientific reports, 2017 - nature.com
… 4i warrants further evaluation as a potential anticancer drug. … Here we describe replacing
the thiazole nucleus with the less … groups as the 3′,4′,5′-trimethoxyphenyl moiety, identical …

Synthesis of new thiazole derivatives and evaluation of their antimicrobial and cytotoxic activities

S Dawbaa, AE Evren, Z Cantürk… - Phosphorus, Sulfur, and …, 2021 - Taylor & Francis
… having a 2,4-disubstituted thiazole ring were reported to have anticancer activity as well as
… [ Citation 36–42 ] Clinically available thiazole-containing anticancer drugs act as inosine 5′-…

2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition

R Romagnoli, MK Salvador, SS Ortega… - European journal of …, 2018 - Elsevier
… target for the development of anticancer agents. Continuing our search … of 2-alkoxycarbonyl-3-(3′,4′,5′-trimethoxyanilino)-5-aryl/…
Synthesis and biological evaluation of 2-methyl-4,5-…

[HTML][HTML] Synthesis, molecular modelling and biological significance of N-(4-(4-bromophenyl) thiazol-2-yl)-2-chloroacetamide derivatives as prospective antimicrobial …

D Sharma, S Kumar, B Narasimhan, K Ramasamy… - BMC chemistry, 2019 - Springer
anticancer agents [20, 21], the present study was undertaken to design, synthesize, molecularly
dock and evaluate the biological … potentials of new synthesized thiazole derivatives are …

Synthesis of thiazole linked chalcones and their pyrimidine analogues as anticancer agents

C Kesari, KR Rama, K Sedighi, J Stenvang… - Synthetic …, 2021 - Taylor & Francis
… In summary, we synthesized and evaluated a novel series of thiazole linked chalcone analogs
as anticancer agents. Many of these thiazole analogs showed significant antiproliferative …